HR Rabbit Polyclonal Antibody (CAB11996)
- SKU:
- CAB11996
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | HR Rabbit Polyclonal Antibody |
SKU: | CAB11996 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human HR (NP_005135.2). |
Sequence: | SLGS KGFY YKDP SIPR LAKE PLAA AEPG LFGL NSGG HLQR AGEA ERPS LHQR DGEM GAGR QQNP CPLF LGQP DTVP WTSW PACP PGLV HTLG NVWA GPGD GNLG YQLG PPAT PRCP SPEP PVTQ RGCC SSYP PTKG GGLG PCGK CQEG LEGG ASGA SEPS EEVN KASG PRAC PPSH HTKL KKTW LTRH SEQF ECPR GCPE VEER PVAR LRAL KRAG SPEV QGAM GSPA PKRP PDPF PGTA EQGA GGWQ EVRD TSIG NKDV DSGQ HDEQ KGPQ DGQA SLQD P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165; HR |
Positive Sample: | U-251MG,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 127kDa |
Observed MW: | 120kDa |
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 55806 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |