The HR Polyclonal Antibody (CAB11996) is specifically designed for research involving HR, a cell surface molecule implicated in immune regulation with a focus on inhibiting immune responses. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot applications. It binds specifically to the HR protein, enabling researchers to detect and analyze its presence in various cell types, making it an ideal tool for studies in immunology and cancer research.
HR, also known as a key immune regulator, plays a vital role in maintaining immune homeostasis by regulating inflammation and suppressing allergic reactions. Its importance in modulating immune responses makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of HR is essential for the development of therapies that can effectively harness or manipulate immune function in these disease contexts.
Product Name:
HR Rabbit Polyclonal Antibody
SKU:
CAB11996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human HR (NP_005135.2).
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
55806
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HR Rabbit pAb (CAB11996) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 40s.
