The HPSE Polyclonal Antibody (CAB16488) is a vital tool for researchers studying Heparanase (HPSE), an enzyme involved in extracellular matrix remodeling and regulation of various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blotting applications. It recognizes the HPSE protein, allowing for accurate detection and analysis in a wide range of cell types, making it ideal for studies in cancer biology and inflammation research.
Heparanase has been shown to play a crucial role in tumor metastasis, angiogenesis, and inflammation. By targeting HPSE with this antibody, researchers can gain valuable insights into its mechanisms of action and potential therapeutic applications in cancer and inflammatory diseases. Understanding the function of HPSE is essential for developing novel therapies that target this enzyme and its pathways for improved treatment outcomes in various disease settings.
Product Name:
Heparanase 1 Rabbit Polyclonal Antibody
SKU:
CAB16488
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 36-275 of human Heparanase 1 (NP_001092010.1).
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Heparanase 1 Rabbit pAb (CAB16488) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
