The HPS4 Polyclonal Antibody (CAB16157) is a valuable tool for researchers studying the HPS4 protein, which is involved in the biogenesis of lysosome-related organelles such as melanosomes and platelet dense granules. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in Western blot applications. By binding specifically to the HPS4 protein, this antibody allows for detection and analysis in various cell types, making it ideal for studies in cell biology and lysosomal storage disorders.HPS4, a subunit of the biogenesis of lysosome-related organelles complex-3 (BLOC-3), plays a critical role in the formation and function of lysosome-related organelles.
Dysregulation of HPS4 is associated with Hermansky-Pudlak syndrome, a rare genetic disorder characterized by albinism, bleeding disorders, and lung fibrosis. Research into the function and regulation of HPS4 is essential for understanding the pathogenesis of lysosomal storage disorders and developing targeted therapies for these conditions.Overall, the HPS4 Polyclonal Antibody (CAB16157) is a valuable tool for researchers investigating the role of HPS4 in lysosome-related organelle biogenesis and associated disorders. Its high specificity and sensitivity make it an essential reagent for studies in cell biology, genetics, and lysosomal storage disorders.
Product Name:
HPS4 Rabbit Polyclonal Antibody
SKU:
CAB16157
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 387-708 of human HPS4 (NP_071364.4).
This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
89781
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using HPS4 Rabbit pAb (CAB16157) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
