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HPRT1 Polyclonal Antibody

SKU:
CAB21825
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

HPRT1 Polyclonal Antibody (CAB21825)

The HPRT1 Polyclonal Antibody (ABM-AB-4970) is a valuable tool for researchers studying the HPRT1 gene, which encodes for the enzyme hypoxanthine-guanine phosphoribosyltransferase 1. This enzyme plays a crucial role in the salvage pathway of purine biosynthesis, making it essential for DNA synthesis and cell proliferation. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it suitable for Western blot applications. By binding to the HPRT1 protein, researchers can accurately detect and analyze its expression levels in various cell types. This makes it an ideal reagent for studies in genetics, cancer research, and drug development.

The HPRT1 gene mutations are associated with Lesch-Nyhan syndrome, a rare inherited disorder characterized by neurological and behavioral abnormalities. Understanding the function and regulation of HPRT1 is important for uncovering the molecular mechanisms underlying purine metabolism disorders and identifying potential therapeutic targets. This antibody facilitates the investigation of HPRT1 expression patterns and activity, providing valuable insights into its role in human health and disease.

Product Name:HPRT1 Polyclonal Antibody
Product Code:CAB21825
Reactivity:Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:C6, Mouse brain, Rat heart
Cellular Location:Cytoplasm

The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human HPRT1 (NP_000185.1).
Sequence:MATRS PGVVI SDDEP GYDLD LFCIP NHYAE DLERV FIPHG LIMDR TERLA RDVMK EMGGH HIVAL CVLKG GYKFF ADLLD YIKAL NRNSD RSIPM TVDFI RLKSY CNDQS TGDIK VIGGD DLSTL TGKNV LIVED IIDTG KTMQT LLSLV RQYNP KMVKV ASLLV KRTPR SVGYK PDFVG FEIPD KFVVG YALDY NEYFR DLNHV CVISE TGKAK YKA
Synonyms:HPRT, HGPRT
Calculated MW:25kDa
Observed MW:25kDa

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