The HPGD Polyclonal Antibody (CAB6926) is a valuable tool for researchers studying the HPGD gene, which encodes the enzyme 15-hydroxyprostaglandin dehydrogenase. This enzyme plays a crucial role in prostaglandin metabolism, particularly in the degradation of prostaglandin E2, a key mediator of inflammation.Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the HPGD protein, this antibody allows for the detection and analysis of HPGD expression in various cell types. Its specificity and sensitivity make it ideal for studies in immunology, inflammation, and cancer research.
Understanding the function of HPGD is essential for unraveling its role in inflammation and its potential implications in diseases such as cancer and inflammatory disorders. By targeting the HPGD enzyme, researchers may uncover new therapeutic strategies for modulating inflammation and prostaglandin signaling pathways. With its versatile applications and reliable performance, the HPGD Polyclonal Antibody (CAB6926) is a valuable asset for scientists investigating the complex interplay between prostaglandins and inflammation.
Product Name:
15-PGDH/HPGD Rabbit Polyclonal Antibody
SKU:
CAB6926
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-266 of human 15-PGDH/15-PGDH/HPGD (NP_000851.2).
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3248
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using 15-PGDH/HPGD Rabbit pAb (CAB6926) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
