The HPCA Polyclonal Antibody (CAB10019) is a vital tool for researchers studying HPCA1, a calcium-binding protein involved in neuronal development and function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the HPCA1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in neuroscience and neurodegenerative diseases.
HPCA1, also known as hippocalcin, plays a crucial role in regulating calcium signaling in neurons and is implicated in processes such as synaptic plasticity and learning. Its involvement in neuronal development and function makes it a key target for research into neurological disorders such as Alzheimer's disease and Parkinson's disease. Understanding the role of HPCA1 is essential for developing potential therapeutic strategies that target calcium signaling pathways in these conditions.
Product Name:
HPCAL1 Rabbit Polyclonal Antibody
SKU:
CAB10019
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human HPCAL1 (NP_002140.2).
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3241
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HPCAL1 Rabbit pAb (CAB10019) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 90s.
