HP1 gamma/CBX3 Rabbit Monoclonal Antibody (CAB4283)
- SKU:
- CAB4283
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | HP1 gamma/CBX3 Rabbit Monoclonal Antibody |
SKU: | CAB4283 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HP1 gamma/CBX3 (NP_057671.2). |
Sequence: | MASN KTTL QKMG KKQN GKSK KVEE AEPE EFVV EKVL DRRV VNGK VEYF LKWK GFTD ADNT WEPE ENLD CPEL IEAF LNSQ KAGK EKDG TKRK SLSD SESD |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | HECH; HP1-GAMMA; HP1Hs-gamma; HP1 gamma/CBX3 |
Positive Sample: | HeLa,SH-SY5Y,Mouse spleen,Mouse thymus,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 21kDa |
Observed MW: | 22kDa |
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 11335 |
Clone Number: | ARC0952 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |