HP1 alpha/CBX5 Rabbit Monoclonal Antibody (CAB3741)
- SKU:
- CAB3741
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | HP1 alpha/CBX5 Rabbit Monoclonal Antibody |
SKU: | CAB3741 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 92-191 of human HP1 alpha/CBX5 (P45973). |
Sequence: | SNFS NSAD DIKS KKKR EQSN DIAR GFER GLEP EKII GATD SCGD LMFL MKWK DTDE ADLV LAKE ANVK CPQI VIAF YEER LTWH AYPE DAEN KEKE TAKS |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HP1; HP1A; HEL25; HP1 alpha/CBX5 |
Positive Sample: | HeLa,293T,MCF7,Mouse lung,Mouse brain,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, centromere. |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method: | Affinity purification |
Gene ID: | 23468 |
Clone Number: | ARC0244 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |