The HP1-Alpha Rabbit Monoclonal Antibody (CAB3741) is a high-quality antibody designed for research involving the HP1-alpha protein, a key regulator of chromatin structure and gene expression. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.HP1-alpha, also known as heterochromatin protein 1-alpha, plays a crucial role in chromatin remodeling and transcriptional regulation. Its involvement in epigenetic processes makes it a valuable target for studies in epigenetics, cancer biology, and development. The HP1-Alpha Rabbit Monoclonal Antibody enables precise detection and analysis of HP1-alpha protein levels in different experimental settings, allowing for a deeper understanding of its functions and contributions to cellular processes.
Researchers interested in exploring the intricate mechanisms of chromatin organization, gene silencing, and transcriptional control will find the HP1-Alpha Rabbit Monoclonal Antibody to be an indispensable tool in their research endeavors. Its specificity and reliability make it well-suited for investigations into the molecular pathways involving HP1-alpha and its implications in various biological processes.
Product Name:
HP1 alpha/CBX5 Rabbit Monoclonal Antibody
SKU:
CAB3741
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 92-191 of human HP1 alpha/CBX5 (P45973).
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
23468
Clone Number:
ARC0244
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HP1 alpha/CBX5Rabbit mAb (CAB3741) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
