The HP Polyclonal Antibody (CAB14186) is a valuable tool for researchers studying the HP protein, a key player in immune regulation and response. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the HP protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in immunology, cancer research, and other related fields.HP, also known as haptoglobin, is a crucial protein involved in the scavenging and binding of free hemoglobin to prevent oxidative damage and regulate inflammation.
Dysregulation of HP has been implicated in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions. By understanding the role of HP in immune modulation, researchers can develop potential therapeutic strategies to target these diseases.Overall, the HP Polyclonal Antibody (CAB14186) offers researchers a powerful tool for investigating the function and significance of HP in immune regulation and disease pathology. Its high reactivity and specificity make it a valuable asset for advancing our understanding of immune responses and developing targeted therapies for various health conditions.
Product Name:
Haptoglobin (HP) Rabbit Polyclonal Antibody
SKU:
CAB14186
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 123-347 of human Haptoglobin (Haptoglobin (HP)) (NP_001119574.1).
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using Haptoglobin (Haptoglobin (HP)) antibody (CAB14186). Blue: DAPI for nuclear staining.
