Haptoglobin (HP) Rabbit Polyclonal Antibody (CAB14186)
- SKU:
- CAB14186
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | Haptoglobin (HP) Rabbit Polyclonal Antibody |
SKU: | CAB14186 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 123-347 of human Haptoglobin (Haptoglobin (HP)) (NP_001119574.1). |
Sequence: | HHNL TTGA TLIN EQWL LTTA KNLF LNHS ENAT AKDI APTL TLYV GKKQ LVEI EKVV LHPN YSQV DIGL IKLK QKVS VNER VMPI CLPS KDYA EVGR VGYV SGWG RNAN FKFT DHLK YVML PVAD QDQC IRHY EGST VPEK KTPK SPVG VQPI LNEH TFCA GMSK YQED TCYG DAGS AFAV HDLE EDTW YATG ILSF DKSC AVAE YGVY VKVT SIQD WVQK TIAE N |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | BP; HPA1S; HP2ALPHA2; Haptoglobin (HP) |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 45kDa |
Observed MW: | Refer to figures |
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3240 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |