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Hp Antibody (PACO33768)

SKU:
PACO33768
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • Hp Antibody PACO33768
  • Hp Antibody PACO33768
€339
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Description

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Hp Antibody (PACO33768)

The HP Antibody (PACO33768) is a highly specific and sensitive polyclonal antibody designed for research involving the HP protein. This antibody is raised in rabbits and is validated for use in various applications, including Western blot and immunohistochemistry. The HP protein, also known as Haptoglobin, plays a crucial role in binding free hemoglobin to prevent oxidative damage and kidney injury. It is a key regulator of the immune response and has been implicated in various diseases, including inflammation, cardiovascular diseases, and cancer.

With its high reactivity with human samples, the HP Antibody is an ideal tool for studying the role of the HP protein in various cell types and tissues. Its specificity and sensitivity make it a valuable asset for researchers working in the fields of immunology, oncology, and systemic diseases. Overall, the HP Antibody (PACO33768) provides researchers with a reliable tool for investigating the function and regulation of the HP protein, advancing our understanding of its role in health and disease.

Antibody Name:Hp Antibody (PACO33768)
Antibody SKU:PACO33768
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200
Species Reactivity:Rat
Immunogen:Recombinant Rat Haptoglobin protein (19-346AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot
All lanes: Hp antibody at 2µg/ml + Rat live tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39, 43 kDa
Observed band size: 39 kDa
.
Product ImageImmunohistochemistry of paraffin-embedded mouse liver tissue using PACO33768 at dilution of 1:50.
Background:As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
Synonyms:Haptoglobin (Liver regeneration-related protein LRRG173) (Zonulin) [Cleaved into: Haptoglobin α chain; Haptoglobin β chain], Hp
UniProt Protein Function:HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:Enzyme, misc.; Protease; Endoplasmic reticulum; Secreted, signal peptide; Secreted

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function:antioxidant activity; hemoglobin binding; protein homodimerization activity; serine-type endopeptidase activity

Biological Process: acute inflammatory response; acute-phase response; defense response to bacterium; immune system process; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; proteolysis; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to X-ray; spermatogenesis

NCBI Summary:may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]
UniProt Code:P06866
NCBI GenInfo Identifier:60097941
NCBI Gene ID:24464
NCBI Accession:NP_036714.2
UniProt Secondary Accession:P06866,Q5EBB4, Q7TP23,
UniProt Related Accession:P06866
Molecular Weight:40.5 kDa
NCBI Full Name:haptoglobin
NCBI Synonym Full Names:haptoglobin
NCBI Official Symbol:Hp  
NCBI Official Synonym Symbols:Ba1-647  
NCBI Protein Information:haptoglobin
UniProt Protein Name:Haptoglobin
UniProt Synonym Protein Names:Liver regeneration-related protein LRRG173; Zonulin
UniProt Gene Name:Hp  
UniProt Entry Name:HPT_RAT
ELISA Kits
Rat Haptoglobin ELISA Kit
Rat HP (Haptoglobin) CLIA Kit (RTES00273)
Rat Haptoglobin (Hp) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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