The HOXD11 Monoclonal Antibody (PAC018080) is a valuable tool for research involving the HOXD11 protein, a transcription factor known for its role in development and differentiation processes. This antibody, produced using hybridoma technology, is highly specific to human samples and is validated for use in various applications, including immunofluorescence and flow cytometry. By targeting the HOXD11 protein, researchers can study its expression and function in different cell types, providing insights into its involvement in developmental biology and disease pathways.HOXD11 is a member of the HOX gene family, which plays a crucial role in regulating embryonic development and tissue patterning.
Aberrant expression of HOXD11 has been linked to various diseases, including cancers and developmental disorders. Understanding the molecular mechanisms controlled by HOXD11 can lead to potential therapeutic targets for treating these conditions. The HOXD11 Monoclonal Antibody offers a powerful tool for investigating the function of HOXD11 in different biological contexts, making it a valuable asset for researchers in the fields of developmental biology and oncology.
Antibody Name:
HOXD11 Antibody (PACO18080)
Antibody SKU:
PACO18080
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:5000, WB:1:1000-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human HOXD11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10+12%SDS-PAGE, Lysate: 30 μg, Lane: Mouse kidney tissue, Primary antibody: PACO18080(HOXD11 Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 60 seconds.
Background:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
Synonyms:
homeobox D11
UniProt Protein Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
NCBI Summary:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
