The HOXD1 Monoclonal Antibody (PACO58576) is a valuable tool for researchers studying the HOXD1 gene, a member of the homeobox gene family involved in the regulation of embryonic development and cell differentiation. This antibody, produced using hybridoma technology, specifically targets the HOXD1 protein and is highly reactive in human samples.Validated for use in various applications including Western blot and immunohistochemistry, this antibody enables the detection and analysis of HOXD1 expression in different cell types and tissues. Its specificity and sensitivity make it an ideal choice for research in developmental biology, regenerative medicine, and cancer biology.
HOXD1 has been implicated in a variety of biological processes, including organ and tissue development, as well as cell fate determination. Dysregulation of HOXD1 expression has been associated with developmental disorders and cancer progression. Investigating the function of HOXD1 and its downstream targets is essential for understanding developmental pathways and disease mechanisms, with the potential for identifying new therapeutic targets in the future.
Western Blot. Positive WB detected in: Rat lung tissue, Rat kidney tissue, Mouse lung tissue. All lanes: HOXD1 antibody at 2.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35 kDa. Observed band size: 35 kDa.
IHC image of PACO58576 diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Synonyms:
Homeobox protein Hox-D1 (Homeobox protein Hox-GG), HOXD1, HOX4 HOX4G
UniProt Protein Function:
HOXD1: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Belongs to the Antp homeobox family. Labial subfamily.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 2q31.1
UniProt Protein Details:
NCBI Summary:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis. [provided by RefSeq, Jul 2008]
