The HOXB8 Monoclonal Antibody (PACO19776) is a valuable tool for research focused on the HOXB8 gene, a critical regulator of cell differentiation and development. This antibody, generated through a monoclonal process, exhibits high specificity and sensitivity for detecting HOXB8 protein in human samples and is suitable for use in various experimental techniques, including Western blotting and immunohistochemistry.HOXB8 is a member of the homeobox family of transcription factors, playing a crucial role in embryonic development and tissue patterning. Dysregulation of HOXB8 has been linked to various diseases, including cancer and developmental disorders.
Research on the function and expression of HOXB8 provides insights into its impact on cell behavior and potential therapeutic interventions for related conditions.By using the HOXB8 Monoclonal Antibody (PACO19776), researchers can delve deeper into the mechanisms underlying HOXB8 function and its significance in various physiological and pathological processes. This antibody serves as a valuable tool for investigations in developmental biology, cancer biology, and regenerative medicine, offering opportunities for new discoveries and advancements in the field.
Antibody Name:
HOXB8 Antibody (PACO19776)
Antibody SKU:
PACO19776
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human HOXB8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: PACO19776(HOXB8 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
Background:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Synonyms:
homeobox B8
UniProt Protein Function:
HOXB8: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 17q21.3Biological Process: negative regulation of myeloid cell differentiation
UniProt Protein Details:
NCBI Summary:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
