The HOXB4 Polyclonal Antibody (CAB16878) is a valuable tool for research involving the HOXB4 protein, a key regulator of hematopoietic stem cell proliferation and differentiation. This antibody, produced in rabbits, is highly specific and reacts strongly with human samples, making it suitable for Western blot applications. By binding to the HOXB4 protein, this antibody enables researchers to analyze and detect HOXB4 expression in various cell types, providing crucial insights into the role of HOXB4 in hematopoiesis and cancer development.
HOXB4, a member of the HOX gene family, plays a crucial role in maintaining the balance between stem cell self-renewal and differentiation in the hematopoietic system. Dysregulation of HOXB4 expression has been implicated in various hematologic disorders and leukemias, highlighting its potential as a therapeutic target. By studying the function of HOXB4 using this polyclonal antibody, researchers can gain valuable knowledge that may lead to the development of novel strategies for treating blood-related diseases.
Product Name:
HOXB4 Rabbit Polyclonal Antibody
SKU:
CAB16878
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HOXB4 (NP_076920.1).
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Purification Method:
Affinity purification
Gene ID:
3214
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HOXB4 Rabbit pAb (CAB16878) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
