The HOXB3 Polyclonal Antibody (PACO59748) is a valuable tool for researchers studying the HOXB3 gene, a member of the HOX gene family involved in embryonic development and cellular differentiation. This antibody, generated in rabbits, shows high specificity and sensitivity for detecting HOXB3 protein in human samples, making it suitable for various research applications, including immunohistochemistry and Western blotting.HOXB3 is known to play a critical role in regulating gene expression patterns that control cell growth and differentiation. Dysregulation of HOXB3 has been linked to various diseases, including cancer and developmental disorders.
By using the HOXB3 Polyclonal Antibody, researchers can gain insights into the function of HOXB3 in different cell types and tissues, paving the way for potential therapeutic strategies targeting this important gene in disease settings.Overall, the HOXB3 Polyclonal Antibody is a reliable tool for investigating the role of HOXB3 in normal development and disease processes, providing valuable information for ongoing research in molecular biology and biomedical sciences.
Antibody Name:
HOXB3 Antibody (PACO59748)
Antibody SKU:
PACO59748
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Homeobox protein Hox-B3 protein (315-423AA)
IHC image of PACO59748 diluted at 1:600 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Synonyms:
Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein Hox-2G), HOXB3, HOX2G
UniProt Protein Function:
HOXB3: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 17q21.3Biological Process: angiogenesis
UniProt Protein Details:
NCBI Summary:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
