The HOXA13 Polyclonal Antibody (CAB13999) is a specialized tool for research involving the HOXA13 gene, a critical regulator of embryonic development and cell differentiation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various immunological assays, including Western blotting.HOXA13 is a transcription factor that plays a crucial role in the formation of body structures during embryonic development, particularly in the development of limbs and genitalia. Mutations in the HOXA13 gene have been associated with a range of developmental disorders, making it a target of interest in research on developmental biology and genetic diseases.
By using the HOXA13 Polyclonal Antibody, researchers can easily detect and analyze the expression of HOXA13 protein in different cell types and tissues, providing valuable insights into its function and regulation. This antibody is a valuable tool for studies on morphogenesis, tissue patterning, and gene regulation, offering new possibilities for understanding and manipulating developmental processes.
Product Name:
HOXA13 Rabbit Polyclonal Antibody
SKU:
CAB13999
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-320 of human HOXA13 (NP_000513.2).
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome.
Purification Method:
Affinity purification
Gene ID:
3209
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HOXA13 antibody (CAB13999) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
