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HOXA11/HOXD11 Antibody (PACO23443)

SKU:
PACO23443
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • HOXA11/HOXD11 Antibody PACO23443
  • HOXA11/HOXD11 Antibody PACO23443
€419
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Description

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HOXA11/HOXD11 Antibody (PACO23443)

The HOXA11/HOXD11 Polyclonal Antibody (PAC023443) is a valuable tool for researchers studying the HOXA11 and HOXD11 proteins, which play key roles in development and differentiation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to the HOXA11 and HOXD11 proteins, allowing for their detection and analysis in various cell types.HOXA11 and HOXD11 are homeobox genes that are involved in the regulation of gene expression and cell differentiation, particularly in the development of the skeletal system and reproductive organs. Dysregulation of these genes has been implicated in a variety of developmental disorders and cancers, making them important targets for research in developmental biology and oncology.

By using the HOXA11/HOXD11 Polyclonal Antibody, researchers can better understand the function and regulation of these critical proteins, leading to insights that could ultimately guide the development of new therapeutic strategies for diseases associated with HOXA11 and HOXD11 dysregulation. Whether investigating developmental abnormalities or cancer progression, this antibody is an essential tool for studying the role of HOXA11 and HOXD11 in cellular processes.

Antibody Name:HOXA11/HOXD11 Antibody (PACO23443)
Antibody SKU:PACO23443
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from internal of human HOXA11/D11.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from RAW264.7 cells, using HOXA11/D11 antibody.
Product ImageImmunofluorescence analysis of HUVEC cells, using HOXA11/D11 antibody.
Background:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Synonyms:Homeobox protein Hox-A11; Hox-1I; HOXA11; HOX1I;
UniProt Protein Function:HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: transcription factor complex; protein complex; nucleus

Molecular Function:sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; developmental growth; anatomical structure morphogenesis; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; male gonad development; uterus development; anterior/posterior pattern formation; positive regulation of chondrocyte differentiation; dorsal/ventral pattern formation; ureteric bud branching; single fertilization; induction of an organ; mesodermal cell fate specification; spermatogenesis; embryonic digit morphogenesis; skeletal development; metanephros development; proximal/distal pattern formation; embryonic limb morphogenesis

Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia

NCBI Summary:In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
UniProt Code:P31270
NCBI GenInfo Identifier:13124744
NCBI Gene ID:3207
NCBI Accession:P31270.2
UniProt Related Accession:P31270
Molecular Weight:
NCBI Full Name:Homeobox protein Hox-A11
NCBI Synonym Full Names:homeobox A11
NCBI Official Symbol:HOXA11  
NCBI Official Synonym Symbols:HOX1; HOX1I; RUSAT1  
NCBI Protein Information:homeobox protein Hox-A11
UniProt Protein Name:Homeobox protein Hox-A11
UniProt Synonym Protein Names:Homeobox protein Hox-1I
UniProt Gene Name:HOXA11  
UniProt Entry Name:HXA11_HUMAN
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