The Hormad2 Polyclonal Antibody (PACO38550) is a vital tool for researchers studying Hormad2, a protein associated with meiosis and DNA repair processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the Hormad2 protein, this antibody enables precise detection and analysis in a range of cell types, making it an invaluable resource for studies in genetics and reproductive biology.Hormad2 is a key player in meiotic chromosome dynamics and DNA double-strand break repair, contributing to the successful progression of meiosis and maintenance of genomic integrity.
As such, research on Hormad2 is crucial for understanding the mechanisms underlying reproductive health and fertility. Additionally, abnormal Hormad2 function has been linked to genetic disorders and infertility, highlighting its importance in clinical and molecular biology research.By utilizing the Hormad2 Polyclonal Antibody, researchers can gain valuable insights into the role of Hormad2 in meiosis and DNA repair, paving the way for advancements in areas such as reproductive medicine and genetic therapy. Investigating the function of Hormad2 may lead to the development of innovative treatments for infertility and genetic diseases, ultimately improving human health and well-being.
Antibody Name:
HORMAD2 Antibody (PACO38550)
Antibody SKU:
PACO38550
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human HORMA domain-containing protein 2 protein (14-307AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO38550 at dilution of 1:100.
Background:
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.
Synonyms:
HORMA domain-containing protein 2, HORMAD2
UniProt Protein Function:
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
