HORMAD1 Antibody (PACO13690)
- SKU:
- PACO13690
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HORMAD1 Antibody (PACO13690)
The Hormad1 Polyclonal Antibody (PAC013690) is a valuable tool for researchers studying Hormad1, a protein involved in meiotic recombination and gametogenesis. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Hormad1 protein, this antibody enables reliable detection and analysis in various cell types, making it suitable for investigations in reproductive biology and fertility research.Hormad1 is essential for the proper alignment and segregation of chromosomes during meiosis, ensuring genetic diversity in gametes. Dysregulation of Hormad1 has been linked to reproductive disorders and infertility, highlighting its importance in reproductive health.
Studying the function and regulation of Hormad1 can provide insights into the molecular mechanisms underlying these conditions, potentially leading to the development of novel therapeutic strategies.Overall, the Hormad1 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of Hormad1 in meiotic recombination and reproductive biology. Its high specificity and sensitivity make it a reliable choice for studying this essential protein in various experimental settings.
| Antibody Name: | HORMAD1 Antibody (PACO13690) |
| Antibody SKU: | PACO13690 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human HORMAD1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | HORMA domain containing 1;HORMAD1;CT46;DKFZp434A1315;NOHMA;RP11-363I22.1 ; |
| UniProt Protein Function: | HORMAD1: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: chromosome; nucleus Biological Process: blastocyst development; meiosis; meiotic DNA double-strand break formation; meiotic recombination checkpoint; meiotic sister chromatid cohesion; oogenesis; spermatogenesis; synaptonemal complex assembly |
| NCBI Summary: | This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q86X24 |
| NCBI GenInfo Identifier: | 74750516 |
| NCBI Gene ID: | 84072 |
| NCBI Accession: | Q86X24.1 |
| UniProt Secondary Accession: | Q86X24,Q4G114, Q5T5I3, Q5T5I4, Q5T5I5, Q6FIC1, Q9H0K8 A6NMK2, B3KUK1, |
| UniProt Related Accession: | Q86X24 |
| Molecular Weight: | 36,676 Da |
| NCBI Full Name: | HORMA domain-containing protein 1 |
| NCBI Synonym Full Names: | HORMA domain containing 1 |
| NCBI Official Symbol: | HORMAD1Â Â |
| NCBI Official Synonym Symbols: | CT46; NOHMAÂ Â |
| NCBI Protein Information: | HORMA domain-containing protein 1 |
| UniProt Protein Name: | HORMA domain-containing protein 1 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein |
| Protein Family: | HORMA domain-containing protein |
| UniProt Gene Name: | HORMAD1Â Â |
| UniProt Entry Name: | HORM1_HUMAN |
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