The Homer3 Polyclonal Antibody (PACO09771) is a valuable tool for researchers studying the Homer3 protein, which is known for its role in intracellular signaling pathways involved in synaptic plasticity and neuronal function. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an essential reagent for Western blot analysis and immunofluorescence studies.Homer3 is a scaffolding protein that plays a crucial role in organizing protein complexes at the postsynaptic density of neurons, where it is involved in regulating neurotransmitter receptors and ion channels. Dysregulation of Homer3 expression has been linked to various neurological disorders, including Alzheimer's disease and schizophrenia, highlighting its importance in neuronal function and synaptic transmission.
By using the Homer3 Polyclonal Antibody, researchers can investigate the expression levels and localization of Homer3 in different cell types and tissues, providing valuable insights into its function in normal physiological processes and disease states. This antibody is a versatile tool for studying the molecular mechanisms underlying synaptic plasticity and cognitive function, offering new opportunities for therapeutic interventions targeting Homer3-related pathways.
homer homolog 3 (Drosophila);HOMER3;HOMER-3;VESL3 ;
UniProt Protein Function:
HOMER3: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Belongs to the Homer family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19p13.11Cellular Component: postsynaptic membrane; cytoplasm; plasma membrane; cell junction; cytosolMolecular Function: protein C-terminus binding; protein domain specific binding; protein binding; metabotropic glutatmate receptor bindingBiological Process: metabotropic glutamate receptor signaling pathway; protein targeting
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
