The HNRNPM Polyclonal Antibody (CAB6937) is a valuable tool for researchers studying HNRNPM, a critical protein involved in gene expression regulation and mRNA processing. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for Western blot applications.HNRNPM, also known as heterogeneous nuclear ribonucleoprotein M, plays a pivotal role in RNA splicing, transport, and stability, making it a key player in various cellular processes. Its dysregulation has been linked to numerous diseases, including cancer, and understanding its function is essential for developing targeted therapies.
By specifically targeting HNRNPM, researchers can analyze its expression levels and activity in different cell types, providing valuable insights into its role in gene regulation and disease pathogenesis. This antibody is a valuable tool for studies in molecular biology, oncology, and gene expression research, offering researchers the opportunity to explore the complex mechanisms underlying HNRNPM function.
Product Name:
HNRNPM Rabbit Polyclonal Antibody
SKU:
CAB6937
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 491-730 of human HNRNPM (NP_005959.2).
CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M; HNRNPM
Positive Sample:
BT-474,HL-60,Mouse thymus,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Nucleus, nucleolus.
Calculated MW:
78kDa
Observed MW:
78kDa
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4670
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HNRNPM Rabbit pAb (CAB6937) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
