The HNRNPL Polyclonal Antibody (CAB12447) is a valuable tool for researchers studying HNRNPL, an important RNA-binding protein involved in various cellular processes, including alternative splicing and mRNA stability. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.HNRNPL plays a critical role in post-transcriptional gene regulation, making it a key player in gene expression control. Dysregulation of HNRNPL has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in cellular function.
By using the HNRNPL Polyclonal Antibody, researchers can accurately detect and analyze HNRNPL protein levels in different cell types, providing valuable insights into its function and potential therapeutic targets. This antibody is an essential tool for studies in molecular biology, oncology, and neuroscience, where understanding the role of HNRNPL is crucial for advancing our knowledge of disease mechanisms and potential treatment strategies.
Product Name:
HNRNPL Rabbit Polyclonal Antibody
SKU:
CAB12447
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 282-589 of human HNRNPL (NP_001524.2).
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3191
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HNRNPL Rabbit pAb (CAB12447) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
