The HNRNPH2 Polyclonal Antibody (CAB12993) is a valuable tool for researchers studying HNRNPH2, a protein involved in RNA processing and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the HNRNPH2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and genetics.HNRNPH2, a member of the heterogeneous nuclear ribonucleoprotein family, plays a crucial role in maintaining RNA stability, splicing, and transport within the cell. Its involvement in post-transcriptional gene regulation highlights its significance in various biological processes, including embryonic development, cell differentiation, and disease progression.
Researchers investigating gene expression and RNA metabolism can benefit from the use of this antibody to further elucidate the functions of HNRNPH2 and its impact on cellular pathways.By utilizing the HNRNPH2 Polyclonal Antibody (CAB12993), researchers can gain valuable insights into the molecular mechanisms governed by HNRNPH2 and its implications in normal physiology and disease conditions. This antibody provides a reliable tool for studying RNA processing and gene regulation, offering new avenues for research in fields such as developmental biology, neurobiology, and cancer biology.
Product Name:
HNRNPH2 Rabbit Polyclonal Antibody
SKU:
CAB12993
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-285 of human HNRNPH2 (NP_062543.1).
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed.
Purification Method:
Affinity purification
Gene ID:
3188
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using HNRNPH2 Rabbit pAb (CAB12993) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
