HNRNPH1/HNRNPH2 Antibody (PACO03275)
- SKU:
- PACO03275
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HNRNPH1/HNRNPH2 Antibody (PACO03275)
The HNRNPH1/HNRNPH2 Polyclonal Antibody (PACO03275) is a valuable tool for researchers studying the HNRNPH1 and HNRNPH2 proteins, which play essential roles in RNA processing and gene regulation. This antibody, raised in rabbits, has high specificity and sensitivity for detecting HNRNPH1 and HNRNPH2 in human samples, making it ideal for use in Western blot and immunohistochemistry applications.HNRNPH1 and HNRNPH2 are RNA-binding proteins involved in alternative splicing, mRNA stability, and other aspects of RNA metabolism. Dysregulation of these proteins has been linked to various diseases, including cancer and neurological disorders.
By targeting HNRNPH1 and HNRNPH2, researchers can gain insights into their functions and how they contribute to disease pathogenesis, leading to potential therapeutic strategies.Overall, the HNRNPH1/HNRNPH2 Polyclonal Antibody is a valuable tool for research in molecular biology, genetics, and disease mechanisms, providing important information for advancing our understanding of RNA biology and its implications for human health.
| Antibody Name: | HNRNPH1/HNRNPH2 Antibody |
| Antibody SKU: | PACO03275 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human hnRNP H. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | HNRNPH1; HNRPH; HNRPH1; Heterogeneous nuclear ribonucleoprotein H; hnRNP H; HNRNPH2; FTP3; HNRPH2; Heterogeneous nuclear ribonucleoprotein H2; hnRNP H2; FTP-3; Heterogeneous nuclear ribonucleoprotein H'; hnRNP H' |
| UniProt Protein Function: | hnRNP H1: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). |
| UniProt Protein Details: | Protein type:RNA splicing; RNA-binding; Spliceosome Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: nucleoplasm; membrane; nucleus Molecular Function:protein binding; RNA binding; nucleotide binding; poly(U) binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA processing; regulation of RNA splicing; RNA splicing; gene expression |
| NCBI Summary: | This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012] |
| UniProt Code: | P31943 |
| NCBI GenInfo Identifier: | 1710632 |
| NCBI Gene ID: | 3187 |
| NCBI Accession: | P31943.4 |
| UniProt Secondary Accession: | P31943,Q6IBM4, B3KW86, D3DWQ2, |
| UniProt Related Accession: | P31943 |
| Molecular Weight: | 449 |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein H |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein H1 (H) |
| NCBI Official Symbol: | HNRNPH1Â Â |
| NCBI Official Synonym Symbols: | HNRPH; HNRPH1; hnRNPHÂ Â |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein H |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein H |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | HNRNPH1Â Â |
| UniProt Entry Name: | HNRH1_HUMAN |
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