The HNRNPDL Polyclonal Antibody (CAB10721) is a vital tool for researchers studying HNRNPDL, a protein involved in RNA binding and processing. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting HNRNPDL in human samples, making it an excellent choice for use in Western blot applications. By targeting the HNRNPDL protein, researchers can easily identify and study its function in various cellular processes, particularly in RNA metabolism and gene expression regulation.HNRNPDL, also known as heterogeneous nuclear ribonucleoprotein D-like, plays a crucial role in the post-transcriptional control of gene expression by binding to RNA molecules and influencing their processing and stability. Understanding the function of HNRNPDL is key to unraveling its impact on cellular activities such as mRNA splicing, transport, and translation.
Research on HNRNPDL can provide insights into its involvement in diseases like cancer, neurodegenerative disorders, and developmental abnormalities, offering potential therapeutic targets for intervention.With its exceptional performance and reliability, the HNRNPDL Polyclonal Antibody (CAB10721) is a valuable asset for investigators exploring the molecular mechanisms of RNA biology and its implications in various pathological conditions. By utilizing this antibody in their experiments, researchers can advance their understanding of HNRNPDL's role in cellular physiology and disease progression, paving the way for innovative discoveries and therapeutic developments.
Product Name:
HNRNPDL Rabbit Polyclonal Antibody
SKU:
CAB10721
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 261-420 of human HNRNPDL (NP_112740.1).
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD.
Purification Method:
Affinity purification
Gene ID:
9987
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HNRNPDL antibody (CAB10721) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
