The HNRNPD Polyclonal Antibody (CAB1828) is specifically designed for researchers studying heterogeneous nuclear ribonucleoprotein D (HNRNPD), a protein involved in various cellular processes, including mRNA processing and transport. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to the HNRNPD protein, researchers can detect and analyze its expression in different cell types, making it an essential tool for studies in molecular biology and cancer research.
HNRNPD, also known as AUF1, is a multifunctional protein that plays a crucial role in post-transcriptional gene regulation, influencing mRNA stability and translation. Dysregulation of HNRNPD has been associated with various diseases, including cancer and neurological disorders, making it a target of interest for researchers seeking to understand its role in disease progression. By investigating the function of HNRNPD, scientists can uncover potential therapeutic targets for treating these conditions.
Product Name:
HNRNPD Rabbit Polyclonal Antibody
SKU:
CAB1828
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human HNRNPD (NP_002129.2).
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
Purification Method:
Affinity purification
Gene ID:
3184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HNRNPD Rabbit pAb (CAB1828) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
