The HNRNPD Polyclonal Antibody (CAB15679) is a valuable tool for researchers studying HNRNPD, a multifunctional protein involved in various cellular processes such as RNA metabolism and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for use in Western blotting and immunohistochemistry applications.HNRNPD, also known as AUF1, is a key player in post-transcriptional gene regulation, playing a role in mRNA stability and translation. Its dysregulation has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
By targeting HNRNPD with this antibody, researchers can gain insights into its function and potential therapeutic implications in these disease contexts.Overall, the HNRNPD Polyclonal Antibody (CAB15679) offers a powerful tool for investigating the complex roles of HNRNPD in cellular processes and disease pathogenesis, advancing our understanding of molecular mechanisms underlying various conditions and paving the way for potential therapeutic interventions.
Product Name:
HNRNPD Rabbit Polyclonal Antibody
SKU:
CAB15679
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human HNRNPD (NP_002129.2).
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
P37; AUF1; AUF1A; HNRPD; hnRNPD0; HNRNPD
Positive Sample:
HeLa,HepG2
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
38kDa
Observed MW:
37-45kDa
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
Purification Method:
Affinity purification
Gene ID:
3184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using HNRNPD Rabbit pAb (CAB15679) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
