The HNRNPC Polyclonal Antibody (CAB19137) is a valuable tool for researchers studying the HNRNPC protein, a key regulator of pre-mRNA processing and RNA metabolism. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By specifically binding to the HNRNPC protein, this antibody enables precise detection and analysis in various cell types, facilitating investigations in the fields of molecular biology and gene expression.HNRNPC, also known as heterogeneous nuclear ribonucleoprotein C, plays a crucial role in mRNA splicing and transport, making it essential for the proper functioning of the cellular machinery.
Dysregulation of HNRNPC has been implicated in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions, underscoring its importance in cellular homeostasis. By studying the function and regulation of HNRNPC, researchers can gain insights into disease mechanisms and potential therapeutic targets for intervention.
Product Name:
hnRNP C Rabbit Polyclonal Antibody
SKU:
CAB19137
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 86-190 of human hnRNP C (NP_112604.2).
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
3183
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using hnRNP C Rabbit pAb (CAB19137) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
