The HNRNPA1 Polyclonal Antibody (CAB7491) is a valuable tool for researchers studying HNRNPA1, a key protein involved in RNA processing and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the HNRNPA1 protein, this antibody enables the detection and analysis of HNRNPA1 in various cell types, making it an ideal choice for investigations in molecular biology and cancer research.
HNRNPA1, also known as heterogeneous nuclear ribonucleoprotein A1, plays a crucial role in RNA metabolism and is involved in various cellular processes, including mRNA splicing, transport, and stability. Dysregulation of HNRNPA1 has been implicated in cancer development and progression, making it a promising target for therapeutic intervention. Studying the function of HNRNPA1 is essential for elucidating its role in disease pathology and may lead to the development of novel treatments targeting this protein.
Product Name:
hnRNP A1 Rabbit Polyclonal Antibody
SKU:
CAB7491
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-372 of human hnRNP A1 (NP_112420.1).
UP 1; ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1
Positive Sample:
A-549,Jurkat,HepG2,HL-60,293T
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
39kDa
Observed MW:
39kDa
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome.
Purification Method:
Affinity purification
Gene ID:
3178
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using hnRNP A1 Rabbit pAb (CAB7491) at 1:200 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
