The HNF4A Polyclonal Antibody (CAB13998) is a valuable tool for researchers studying the Hepatocyte Nuclear Factor 4 Alpha (HNF4A) protein, a transcription factor that plays a critical role in regulating gene expression in the liver and pancreas. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.HNF4A is essential for the development and function of the liver and pancreas, playing a key role in glucose and lipid metabolism as well as cell differentiation and proliferation.
Dysregulation of HNF4A has been linked to various diseases, including diabetes, liver disease, and certain types of cancer. By targeting the HNF4A protein, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.Overall, the HNF4A Polyclonal Antibody is a reliable tool for studying the function of HNF4A in both normal physiological processes and disease states, making it a valuable asset for research in the fields of molecular biology, metabolism, and precision medicine.
Product Name:
HNF4A Rabbit Polyclonal Antibody
SKU:
CAB13998
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 155-254 of human HNF4A (NP_000448.3).
Sequence:
LLQA EVLS RQIT SPVS GING DIRA KKIA SIAD VCES MKEQ LLVL VEWA KYIP AFCE LPLD DQVA LLRA HAGE HLLL GATK RSMV FKDV LLLG NDYI VPRH
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
Purification Method:
Affinity purification
Gene ID:
3172
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse liver, using HNF4A antibody (CAB13998) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
