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HNF4A/HNF4G Antibody (PACO00920)

SKU:
PACO00920
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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HNF4A/HNF4G Antibody (PACO00920)

The HNF4A/HNF4G Polyclonal Antibody (PAC00920) is a valuable tool for researchers studying the Hepatocyte Nuclear Factor 4 (HNF4) family of transcription factors. HNF4A and HNF4G are key regulators of gene expression in the liver, pancreas, and colon, with roles in metabolism, development, and disease.This antibody, derived from rabbits, is highly specific and reactive with both human and mouse samples, making it versatile for a range of experimental applications. Validated for use in Western blotting, immunofluorescence, and immunohistochemistry, it allows for the detection and localization of HNF4A and HNF4G proteins in various tissues and cell types.

By targeting HNF4A and HNF4G, researchers can gain insights into the molecular mechanisms underlying metabolic diseases, such as diabetes and liver disorders. Understanding the functions of these transcription factors may lead to the development of novel therapeutic approaches for treating metabolic disorders and improving patient outcomes. Overall, the HNF4A/HNF4G Polyclonal Antibody (PAC00920) is a valuable tool for investigating the roles of HNF4A and HNF4G in health and disease, providing researchers with the means to advance our understanding of metabolic regulation and potentially identify new targets for drug development.

Antibody Name:HNF4A/HNF4G Antibody
Antibody SKU:PACO00920
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human HNF-4alpha/gamma.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HNF4A; HNF4; NR2A1; TCF14; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4; HNF4G; NR2A2; Hepatocyte nuclear factor 4-gamma; HNF-4-ga
UniProt Protein Function:HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Nuclear receptor; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; DNA binding; zinc ion binding; steroid hormone receptor activity; transcription factor activity; fatty acid binding; receptor binding

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of lipid metabolic process; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; lipid homeostasis; glucose homeostasis; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; xenobiotic metabolic process; regulation of gastrulation; response to glucose stimulus; ornithine metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; negative regulation of cell growth; blood coagulation; regulation of insulin secretion; sex differentiation; phospholipid homeostasis

Disease: Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1; Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
UniProt Code:P41235
NCBI GenInfo Identifier:148886624
NCBI Gene ID:3172
NCBI Accession:P41235.3
UniProt Secondary Accession:P41235,O00659, O00723, Q14540, Q5QPB8, Q6B4V5, Q6B4V6 Q6B4V7, Q92653, Q92654, A5JW41, B2RPP8,
UniProt Related Accession:P41235
Molecular Weight:
NCBI Full Name:Hepatocyte nuclear factor 4-alpha
NCBI Synonym Full Names:hepatocyte nuclear factor 4, alpha
NCBI Official Symbol:HNF4A  
NCBI Official Synonym Symbols:TCF; HNF4; MODY; FRTS4; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha  
NCBI Protein Information:hepatocyte nuclear factor 4-alpha; TCF-14; HNF4alpha10/11/12; transcription factor 14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1
UniProt Protein Name:Hepatocyte nuclear factor 4-alpha
UniProt Synonym Protein Names:Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4
Protein Family:Hepatocyte nuclear factor
UniProt Gene Name:HNF4A  
UniProt Entry Name:HNF4A_HUMAN

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