The HMX2 Polyclonal Antibody (PACO58789) is a valuable tool for research involving HMX2, a transcription factor involved in embryonic development and cell differentiation. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in various applications such as Western blotting.HMX2 is known to play a crucial role in development processes, particularly in the formation of sensory organs and tissues. Its expression is also linked to the regulation of neuronal differentiation and function. By targeting the HMX2 protein, researchers can further investigate its functions and molecular pathways, providing insights into its involvement in developmental biology and disease mechanisms.
Studies using the HMX2 Polyclonal Antibody can contribute to a better understanding of HMX2's role in development and disease, opening up new possibilities for therapeutic interventions and potential targets for drug discovery. As an essential research tool, this antibody offers great potential for advancing scientific knowledge in the fields of developmental biology and neurology.
IHC image of PACO58789 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO58789 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.
Synonyms:
Homeobox protein HMX2 (Homeobox protein H6 family member 2), HMX2
UniProt Protein Function:
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012]
