The HMOX1 Polyclonal Antibody is a valuable tool for researchers studying heme oxygenase 1 (HMOX1), an enzyme involved in the breakdown of heme into biliverdin, carbon monoxide, and iron. This antibody, produced using rabbits, demonstrates a high level of reactivity with human samples and has been specifically validated for use in Western blot applications.HMOX1 plays a crucial role in various physiological processes, including antioxidative defense, anti-inflammatory responses, and cell proliferation. Dysregulation of HMOX1 has been linked to numerous pathological conditions, such as cancer, neurodegenerative diseases, and cardiovascular disorders.
As a result, the HMOX1 Polyclonal Antibody serves as a valuable tool for researchers investigating the role of this enzyme in health and disease.By utilizing this antibody, researchers can effectively detect and analyze HMOX1 expression in different cell types, enabling further exploration into its function and molecular mechanisms. With its high specificity and sensitivity, the HMOX1 Polyclonal Antibody is an essential resource for advancing our understanding of heme metabolism and its implications in various disease states.
Product Name:
Hmox1 Polyclonal Antibody
SKU:
CAB23650
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 1-266 of mouse Hmox1(NP_034572.1).
Predicted to enable several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and protein homodimerization activity. Acts upstream of or within several processes, including cellular response to cisplatin; cellular response to metal ion; and regulation of macroautophagy. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1).
Purification Method:
Affinity purification
Gene ID:
15368
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells using Hmox1 Rabbit pAb (CAB23650) at 1:1000 dilution. NIH/3T3 cells were treated by arsenite(50 μM) at 37℃ for 8 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
