null

HMOX1 Monoclonal Antibody [PAT1D6AT] (CPAB0253)

SKU:
CPAB0253
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT1D6AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

HMOX1 Monoclonal Antibody [PAT1D6AT] (CPAB0253)

The HMOX1 Antibody (CPAB0253) is a valuable tool for researchers studying heme oxygenase 1 (HMOX1), an enzyme involved in heme catabolism and the oxidative stress response. Raised in rabbits, this polyclonal antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the HMOX1 protein, this antibody enables the detection and analysis of HMOX1 expression in various cell types, making it ideal for research in areas such as oxidative stress, inflammation, and cancer biology.HMOX1 is a critical enzyme in the regulation of cellular stress responses, playing a key role in maintaining cellular homeostasis and protecting cells from oxidative damage.

Dysregulation of HMOX1 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Understanding the expression and activity of HMOX1 is essential for developing targeted therapeutic strategies aimed at modulating oxidative stress and inflammation in these disease contexts.Overall, the HMOX1 Antibody (CPAB0253) offers researchers a reliable tool for investigating the role of HMOX1 in cellular stress responses and disease pathogenesis, paving the way for the development of novel therapeutic interventions targeting oxidative stress-related disorders.

Product Name:HMOX1 Antibody
Product Sku:CPAB0253
Size:5μg
Host Species:Mouse
Immunogen:Anti-human HMOX1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HMOX1 amino acids 1-266 purified from Ecoli.
Clone:PAT1D6AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:HMOX1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:HMOX1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is then converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HMOX1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme Oxygenase-1 is involved in the regulation of cardiovascular function and its adaptive response to a variety of stressors. HMOX1 is induced in the colon of ulcerative colitis. HMOX1 is found to overexpress with a higher extent of intraplaque angiogenesis implies a multi-faceted role for HMOX1 in modulating the progression of atherosclerosis. HMOX1 expression reduced LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha in murine and human macrophages.
Synonyms:HO-1, HSP32, bK286B10, HMOX-1, Heme oxygenase 1, HMOX1, HO, HO1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Related Products