HMGN5 Antibody (PACO18784)
- SKU:
- PACO18784
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HMGN5 Antibody (PACO18784)
The HMGN5 Polyclonal Antibody (PAC018784) is a valuable tool for researchers studying HMGN5, a protein known for its role in chromatin organization and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity towards HMGN5 in human samples and is validated for use in Western blot applications. By targeting the HMGN5 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in epigenetics and gene regulation.HMGN5, a member of the high mobility group nucleosome-binding protein family, is involved in modulating chromatin structure and promoting transcriptional activation.
Its function in gene regulation makes it a key player in processes such as cell differentiation, development, and disease. Research on HMGN5 is vital for understanding how changes in chromatin organization impact gene expression and cellular function, with implications for diseases like cancer, neurodegenerative disorders, and developmental abnormalities. By investigating the role of HMGN5, researchers can uncover new insights into gene regulation mechanisms and potentially identify novel therapeutic targets for various conditions.
| Antibody Name: | HMGN5 Antibody (PACO18784) |
| Antibody SKU: | PACO18784 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human HMGN5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18784(HMGN5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. |
| Synonyms: | High mobility group nucleosome binding domain 5 |
| UniProt Protein Function: | NSBP1: Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Belongs to the HMGN family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq13.3 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:chromatin binding Biological Process: negative regulation of apoptosis; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P82970 |
| NCBI GenInfo Identifier: | 23396771 |
| NCBI Gene ID: | 79366 |
| NCBI Accession: | P82970.1 |
| UniProt Secondary Accession: | P82970,Q5JSL1, |
| UniProt Related Accession: | P82970 |
| Molecular Weight: | 31,525 Da |
| NCBI Full Name: | High mobility group nucleosome-binding domain-containing protein 5 |
| NCBI Synonym Full Names: | high mobility group nucleosome binding domain 5 |
| NCBI Official Symbol: | HMGN5Â Â |
| NCBI Official Synonym Symbols: | NSBP1; NBP-45Â Â |
| NCBI Protein Information: | high mobility group nucleosome-binding domain-containing protein 5 |
| UniProt Protein Name: | High mobility group nucleosome-binding domain-containing protein 5 |
| UniProt Synonym Protein Names: | Nucleosome-binding protein 1 |
| Protein Family: | High mobility group nucleosome-binding domain-containing protein |
| UniProt Gene Name: | HMGN5Â Â |
| UniProt Entry Name: | HMGN5_HUMAN |
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