The HMGN2 Polyclonal Antibody (CAB6156) is a valuable tool for researchers studying HMGN2, a protein known for its role in chromatin remodeling and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.HMGN2, a member of the High Mobility Group N (HMGN) protein family, is involved in the modulation of chromatin structure and gene expression, impacting various cellular processes such as transcription, DNA repair, and differentiation. By targeting HMGN2, researchers can investigate its impact on gene regulation and its potential implications in diseases like cancer and developmental disorders.
With its specificity for HMGN2, this antibody enables accurate detection and analysis of the protein in different cell types, offering valuable insights into the mechanisms underlying chromatin dynamics and gene regulation. Its application in research areas like epigenetics, cancer biology, and developmental biology makes it a versatile tool for investigators aiming to elucidate the functions of HMGN2 and its involvement in cellular processes.
Product Name:
HMGN2 Rabbit Polyclonal Antibody
SKU:
CAB6156
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human HMGN2 (NP_005508.1).
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi.
Purification Method:
Affinity purification
Gene ID:
3151
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HMGN2 antibody (CAB6156) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
