The HMGCS1 Polyclonal Antibody (CAB3916) is a valuable tool for research involving HMGCS1, a key enzyme in the ketogenesis pathway responsible for catalyzing the formation of HMG-CoA. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the HMGCS1 protein, this antibody allows for the accurate detection and analysis of HMGCS1 in various cell types, making it an ideal choice for studies in metabolism, lipid metabolism, and metabolic diseases.HMGCS1 plays a crucial role in energy metabolism, specifically in the production of ketone bodies during times of fasting or low carbohydrate intake.
Dysregulation of HMGCS1 has been linked to metabolic disorders such as diabetes, obesity, and cardiovascular diseases. Research involving HMGCS1 and its regulation is essential for understanding the underlying mechanisms of these diseases and developing targeted therapies.The HMGCS1 Polyclonal Antibody (CAB3916) offers researchers a reliable tool for investigating the role of HMGCS1 in metabolic pathways, providing valuable insights into the molecular mechanisms underlying metabolic diseases and potential therapeutic targets.
Product Name:
HMGCS1 Rabbit Polyclonal Antibody
SKU:
CAB3916
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 241-520 of human HMGCS1 (NP_002121.4).
Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol.
Purification Method:
Affinity purification
Gene ID:
3157
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HMGCS1 Rabbit pAb (CAB3916) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
