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HMGCR Polyclonal Antibody

SKU:
CAB21451
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
$155 - $431
Frequently bought together:

Description

HMGCR Polyclonal Antibody (CAB21451)

The HMGCR Polyclonal Antibody (AB10001) is a valuable tool for researchers studying the HMG-CoA reductase enzyme, which plays a key role in cholesterol biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.HMGCR is a target for statin drugs used to lower cholesterol levels, making it a critical enzyme in lipid metabolism. Dysregulation of HMGCR activity has been linked to cardiovascular disease and other metabolic disorders, making it a promising target for therapeutic interventions.

By utilizing the HMGCR Polyclonal Antibody, researchers can study the expression and function of HMGCR in different cell types and tissues, providing valuable insights into cholesterol metabolism and potential drug targets for related diseases. This antibody is an essential tool for studies in lipid biology, cardiovascular research, and drug development.

Product Name:HMGCR Polyclonal Antibody
Product Code:CAB21451
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 692-791 of human HMGCR (NP_000850.1).
Sequence:KPAAI NWIEG RGKSV VCEAV IPAKV VREVL KTTTE AMIEV NINKN LVGSA MAGSI GGYNA HAANI VTAIY IACGQ DAAQN VGSSN CITLM EASGP TNEDL
Synonyms:LDLCQ3
Calculated MW:97kDa
Observed MW:Refer to figures

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