HMGCR Rabbit Polyclonal Antibody (CAB16875)
- SKU:
- CAB16875
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | HMGCR Rabbit Polyclonal Antibody |
SKU: | CAB16875 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 731-830 of human HMGCR (NP_000850.1). |
Sequence: | VNIN KNLV GSAM AGSI GGYN AHAA NIVT AIYI ACGQ DAAQ NVGS SNCI TLME ASGP TNED LYIS CTMP SIEI GTVG GGTN LLPQ QACL QMLG VQGA CKDN |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:200 |
Synonyms: | LDLCQ3; HMGCR |
Positive Sample: | U-251MG,HepG2,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 97kDa |
Observed MW: | 100kDa |
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3156 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |