The HMGCR Polyclonal Antibody (CAB1633) is a valuable tool for researchers studying HMGCR, a key enzyme in the cholesterol biosynthesis pathway. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the HMGCR protein, this antibody allows for the detection and analysis of this important enzyme in various cell types, making it ideal for studies in lipid metabolism and cardiovascular disease research.HMGCR, also known as 3-hydroxy-3-methylglutaryl-coenzyme A reductase, plays a crucial role in regulating cholesterol levels in the body. Dysregulation of HMGCR activity has been linked to conditions such as hypercholesterolemia and atherosclerosis, making it a promising target for therapeutic interventions.
Research on HMGCR can provide valuable insights into the mechanisms underlying these diseases and lead to the development of novel treatment strategies aimed at reducing cardiovascular risk factors.The HMGCR Polyclonal Antibody (CAB1633) offers researchers a reliable tool for studying the expression and function of HMGCR in various biological samples. Its specificity and sensitivity make it a valuable asset for investigating the role of this enzyme in health and disease, paving the way for advancements in the field of lipid metabolism and cardiovascular research.
Product Name:
HMGCR Rabbit Polyclonal Antibody
SKU:
CAB1633
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 731-830 of human HMGCR (NP_000850.1).
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3156
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using HMGCR Rabbit pAb (CAB1633) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
