[KO Validated] HMGCR Rabbit Polyclonal Antibody (CAB14741)
- SKU:
- CAB14741
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | [KO Validated] HMGCR Rabbit Polyclonal Antibody |
SKU: | CAB14741 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1). |
Sequence: | ARLQ KLHT SIAG RNLY IRFQ SRSG DAMG MNMI SKGT EKAL SKLH EYFP EMQI LAVS GNYC TDKK PAAI NWIE GRGK SVVC EAVI PAKV VREV LKTT TEAM IEVN INKN LVGS AMAG SIGG YNAH AANI VTAI YIAC GQDA AQNV GSSN CITL MEAS GPTN EDLY ISCT MPSI EIGT VGGG TNLL PQQA CLQM LGVQ GACK DNPG ENAR QLAR IVCG TVMA GELS LMAA LAAG HLVK SHMI HNRS KINL QDLQ GACT KKTA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LDLCQ3; [KD Validated] HMGCR |
Positive Sample: | HepG2,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 97kDa |
Observed MW: | 101kDa |
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3156 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |