HMGCR Rabbit Polyclonal Antibody (CAB13314)
- SKU:
- CAB13314
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | HMGCR Rabbit Polyclonal Antibody |
SKU: | CAB13314 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 426-888 of human HMGCR (NP_000850.1). |
Sequence: | SSVL VTQE PEIE LPRE PRPN EECL QILG NAEK GAKF LSDA EIIQ LVNA KHIP AYKL ETLM ETHE RGVS IRRQ LLSK KLSE PSSL QYLP YRDY NYSL VMGA CCEN VIGY MPIP VGVA GPLC LDEK EFQV PMAT TEGC LVAS TNRG CRAI GLGG GASS RVLA DGMT RGPV VRLP RACD SAEV KAWL ETSE GFAV IKEA FDST SRFA RLQK LHTS IAGR NLYI RFQS RSGD AMGM NMIS KGTE KALS KLHE YFPE MQIL AVSG NYCT DKKP AAIN WIEG RGKS VVCE AVIP AKVV REVL KTTT EAMI EVNI NKNL VGSA MAGS IGGY NAHA ANIV TAIY IACG QDAA QNVG SSNC ITLM EASG PTNE DLYI SCTM PSIE IGTV GGGT NLLP QQAC LQML GVQG ACKD NPGE NARQ LARI VCGT VMAG ELSL MAAL AAGH LVKS HMIH NRSK INLQ DLQG ACTK KTA |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | LDLCQ3; HMGCR |
Positive Sample: | HeLa,Mouse spleen,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 97kDa |
Observed MW: | 100kDa |
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3156 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |