UniProt Protein Function: | HMGCLL1: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Belongs to the HMG-CoA lyase family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: EC 4.1.3.4; LyaseChromosomal Location of Human Ortholog: 6p12.1Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasmMolecular Function: hydroxymethylglutaryl-CoA lyase activity; metal ion bindingBiological Process: cellular lipid metabolic process; ketone body biosynthetic process; ketone body metabolic process |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q8TB92 |
NCBI GenInfo Identifier: | 109150422 |
NCBI Gene ID: | 54511 |
NCBI Accession: | NP_001035865.1 |
UniProt Secondary Accession: | Q8TB92,Q6ZSA9, B1AQ42, B3KNV0, B7Z1S7, F8W793 |
UniProt Related Accession: | Q8TB92 |
Molecular Weight: | 32,701 Da |
NCBI Full Name: | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform b |
NCBI Synonym Full Names: | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 |
NCBI Official Symbol: | HMGCLL1Â Â |
NCBI Official Synonym Symbols: | er-cHL; bA418P12.1Â Â |
NCBI Protein Information: | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic |
UniProt Protein Name: | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic |
UniProt Synonym Protein Names: | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1; Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase; er-cHL |
Protein Family: | 3-hydroxymethyl-3-methylglutaryl-CoA lyase |
UniProt Gene Name: | HMGCLL1Â Â |
UniProt Entry Name: | HMGC2_HUMAN |