The HMGCLL1 Antibody (PAC039722) is a polyclonal antibody designed for research involving HMGCLL1, a protein involved in cholesterol metabolism. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It specifically binds to the HMGCLL1 protein, allowing for detection and analysis in various cell types.HMGCLL1 is a key enzyme in the mevalonate pathway, which plays a crucial role in the synthesis of cholesterol. Dysregulation of this pathway has been associated with various diseases, including metabolic disorders and cancer.
Research on HMGCLL1 can provide insights into the mechanisms underlying these conditions, potentially leading to the development of novel therapeutic strategies.Overall, the HMGCLL1 Antibody is a valuable tool for scientists studying cholesterol metabolism, metabolic disorders, and cancer. Its high reactivity and specificity make it ideal for immunology and cancer research applications.
Antibody Name:
HMGCLL1 Antibody (PACO39722)
Antibody SKU:
PACO39722
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic protein (2-340AA)
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
HMGCLL1: Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Belongs to the HMG-CoA lyase family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: EC 4.1.3.4; LyaseChromosomal Location of Human Ortholog: 6p12.1Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasmMolecular Function: hydroxymethylglutaryl-CoA lyase activity; metal ion bindingBiological Process: cellular lipid metabolic process; ketone body biosynthetic process; ketone body metabolic process
