The HMGB3 Polyclonal Antibody (CAB15064) is a crucial tool for researchers studying the HMGB3 protein, a member of the high mobility group box (HMGB) protein family involved in DNA binding and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to HMGB3, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential asset for studies in molecular biology and cancer research.HMGB3 plays a key role in regulating gene expression, DNA repair, and chromatin structure, making it a significant target for research on cancer, inflammation, and other diseases.
Understanding the functions and mechanisms of HMGB3 can provide valuable insights into the molecular pathways underlying these conditions, ultimately aiding in the development of targeted therapies and diagnostic tools. The HMGB3 Polyclonal Antibody is a valuable resource for researchers seeking to explore the complex role of HMGB3 in cellular processes and disease pathogenesis.
Product Name:
HMGB3 Rabbit Polyclonal Antibody
SKU:
CAB15064
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HMGB3 (NP_005333.2).
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3149
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat thymus, using HMGB3 antibody (CAB15064) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
