The HMGB2 Rabbit Monoclonal Antibody (CAB9168) is a valuable tool for researchers studying HMGB2, a protein involved in DNA binding and transcription regulation. This antibody, developed using rabbit monoclonal technology, has high specificity and sensitivity for detecting HMGB2 in human samples. Validated for use in Western blot and immunohistochemistry applications, it allows for precise detection and analysis of HMGB2 expression in various cell types.HMGB2, a member of the high mobility group box protein family, plays a crucial role in chromatin organization and gene expression regulation. Its involvement in processes like DNA repair, replication, and transcription make it a key player in cellular function and development.
Research on HMGB2 is essential for understanding its impact on various biological processes and its potential implications in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions.By utilizing the HMGB2 Rabbit Monoclonal Antibody (CAB9168), researchers can delve deeper into the functions and mechanisms of HMGB2, ultimately leading to advancements in our knowledge of gene regulation and potential therapeutic targets in human health and disease.
Product Name:
HMGB2 Rabbit Monoclonal Antibody
SKU:
CAB9168
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HMGB2 (P26583).
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Purification Method:
Affinity purification
Gene ID:
3148
Clone Number:
ARC1460
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
CUT&Tag was performed using the CUT&Tag Assay Kit (pAG-Tn5) for Illumina(RK20265) from 10⁵ K562 cells with 1μg HMGB2 Rabbit mAb(CAB9168), along with a Goat Anti-Rabbit IgG(H+L). The CUT&Tag results indicate the enrichment pattern of HMGB2 in representative gene loci (PTBP1), as shown in figure.
