The HMGB2 Polyclonal Antibody (CAB17360) is a valuable tool for researchers studying the HMGB2 protein, a nuclear protein involved in chromatin structure and gene expression regulation. This antibody, raised in rabbits, is highly specific for human samples and is suitable for use in Western blot applications.HMGB2, a member of the high mobility group box (HMGB) family, is known to play important roles in DNA repair, transcriptional regulation, and inflammation. Its overexpression has been linked to various diseases, including cancer, autoimmune disorders, and neurodegenerative conditions.
By targeting HMGB2 with this antibody, researchers can investigate its function in different cell types and gain insights into its potential therapeutic implications.With its high reactivity and specificity, the HMGB2 Polyclonal Antibody is a valuable tool for studies in molecular biology, cellular biology, and disease mechanisms. Its ability to bind to HMGB2 protein allows for accurate detection and analysis, making it an essential component in research aimed at understanding the role of HMGB2 in health and disease.
Product Name:
HMGB2 Rabbit Polyclonal Antibody
SKU:
CAB17360
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HMGB2 (NP_002120.1).
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Purification Method:
Affinity purification
Gene ID:
3148
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HMGB2 Rabbit pAb (CAB17360) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
