Hmgb1 Antibody (PACO64271)
- SKU:
- PACO64271
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Hmgb1 Antibody (PACO64271)
The HMGB1 Polyclonal Antibody (PAC064271) is a vital tool for researchers studying HMGB1, a protein that plays a crucial role in inflammation, immunity, and cancer. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting HMGB1 in human samples, making it an excellent choice for Western blot applications. By binding to HMGB1, this antibody enables accurate quantification and analysis of HMGB1 levels in various cell types, making it invaluable for studies in immunology and oncology research.HMGB1, also known as high mobility group box 1, is a key mediator in inflammatory processes and immune responses, making it a promising target for therapeutic interventions in conditions such as cancer, sepsis, and autoimmune diseases.
Research into the function and regulation of HMGB1 is critical for developing targeted therapies that modulate inflammation and immune responses in disease settings.Utilize the HMGB1 Polyclonal Antibody (PAC064271) to advance your research in understanding the role of HMGB1 in disease pathology, immune regulation, and potential therapeutic targeting. With its exceptional performance and reliability, this antibody is a valuable asset for investigators in immunology, oncology, and inflammation research fields.
| Antibody Name: | Hmgb1 Antibody (PACO64271) |
| Antibody SKU: | PACO64271 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:1000-1:5000 |
| Species Reactivity: | Rat |
| Immunogen: | Peptide sequence from Rat Hmgb1 protein (2-18AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat Brain tissue. All lanes: Hmgb1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 25 kDa. Observed band size: 30 kDa. |
| Background: | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acid,. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acid, implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid, (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins. |
| Synonyms: | High mobility group protein B1 (Amphoterin) (Heparin-binding protein p30) (High mobility group protein 1) (HMG-1), Hmgb1, Hmg-1 Hmg1 |
| UniProt Protein Function: | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins. |
| NCBI Summary: | heparin binding protein that facilitates neurite outgrowth [RGD, Feb 2006] |
| UniProt Code: | P63159 |
| NCBI GenInfo Identifier: | 6981026 |
| NCBI Gene ID: | 25459 |
| NCBI Accession: | NP_037095.1 |
| UniProt Secondary Accession: | P63159,P07155, P27109, P27428, Q548R9, |
| UniProt Related Accession: | P63159 |
| Molecular Weight: | 24,894 Da |
| NCBI Full Name: | high mobility group protein B1 |
| NCBI Synonym Full Names: | high mobility group box 1 |
| NCBI Official Symbol: | Hmgb1Â Â |
| NCBI Official Synonym Symbols: | Hmg1; Ac2-008Â Â |
| NCBI Protein Information: | high mobility group protein B1 |
| UniProt Protein Name: | High mobility group protein B1 |
| UniProt Synonym Protein Names: | Amphoterin; Heparin-binding protein p30; High mobility group protein 1; HMG-1 |
| Protein Family: | High mobility group protein |
| UniProt Gene Name: | Hmgb1Â Â |
| ELISA Kits |
| Rat HMGB1 ELISA Kit |
| Rat HMGB-1 (High Mobility Group Protein B1) CLIA Kit (RTES00299) |
| Rat High mobility group protein B1 (Hmgb1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
HMGB1 Monoclonal Antibody [PJ2E1AT] (CPAB0531)
€149
[KO Validated] HMGB1 Rabbit Monoclonal Antibody (CAB19529)
€139 - €419
[KO Validated] HMGB1 Rabbit Polyclonal Antibody (CAB2553)
€139 - €419
[KO Validated] Acetyl-HMGB1-K29 Rabbit Polyclonal Antibody (CAB16002)
€139 - €419
Rat HMGB1 ELISA Kit
€649
img:cited-250-x-100-px-125-x-75-px-.png
Mouse HMGB1 ELISA Kit
€649