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HMGB1 Monoclonal Antibody [PJ2E1AT] (CPAB0531)

SKU:
CPAB0531
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PJ2E1AT
Applications:
WB
ELISA
IHC
€149
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Description

system_update_alt Datasheet

HMGB1 Monoclonal Antibody [PJ2E1AT] (CPAB0531)

The HMGB1 Polyclonal Antibody (CPAB0531) is an essential tool for researchers studying HMGB1, a highly conserved nuclear protein that plays a critical role in inflammation, immunity, and cancer. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the HMGB1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and oncology research.

HMGB1, also known as high mobility group box 1 protein, is a potent inflammatory mediator released by damaged or necrotic cells. Its involvement in immune response regulation and tumor progression makes it a valuable target for understanding the mechanisms underlying various diseases, such as cancer, sepsis, and autoimmune disorders. The HMGB1 Polyclonal Antibody is a crucial tool for researchers aiming to elucidate the functions of HMGB1 and develop novel therapeutic strategies targeting this protein.

Product Name:HMGB1 Antibody
Product Sku:CPAB0531
Size:5μg
Host Species:Mouse
Immunogen:Anti-human HMGB1 mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HMGB1 amino acids 1-215 purified from High Five (Trichoplusia ni) insect cells.
Clone:PJ2E1AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:HMGB1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 70 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 30 aa C-terminal region that contains only Asp and Glu.4, 5 Residues 27 - 43 and 178 - 184 contain a NLS. Posttranslational modifications of the molecule have been reported, with acetylation occurring on as many as 17 lysine residues. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins.
Synonyms:HMG1, HMG3, SBP-1, Amphoterin, HMGB1, High-Mobility Group Box 1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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